Chain-like cobalt (Co) mesospheres were utilized as templates to synthesize non-platinum AuPd bimetallic catalysts through a two-step galvanic replacement reaction (GRR) with gold (Au) and palladium (Pd) precursors. The AuPd-Cl(50) catalyst, synthesized using NaAuCl4, demonstrated excellent oxygen reduction reaction (ORR) activity due to its high surface area and porous structure. Compared to commercial Pt-20/C and Pd-20/C catalysts, it exhibited a lower onset potential, higher limiting current density, and improved electron transfer number (n value). Koutecky-Levich plot analysis confirmed that the ORR primarily follows a four-electron transfer pathway. Moreover, methanol tolerance and durability tests revealed superior performance, highlighting the potential of AuPd-Cl(50) as a cost-effective and efficient alternative to platinum for alkaline and methanol-based fuel cells.